ORTHOFLUOROANILINE
Chemical properties:
- CAS number: 348-54-9
- Orthofluoroaniline, also known as 2-fluoroaniline, has the chemical formula
C6H6FN and a molar mass of 111.12 g/mol.
- It is a pale yellow to brown crystalline solid with a melting point of 60-64°C
and a boiling point of 245-246°C.
- Orthofluoroaniline is slightly soluble in water (0.30 g/100 mL at 25°C) and is
soluble in organic solvents such as ethanol, acetone, and chloroform.
- It has a density of 1.219 g/cm³ and a vapor pressure of 0.18 mmHg at 25°C.
- Orthofluoroaniline is a weakly basic compound, with a pKa of 4.99.
Applications:
- Orthofluoroaniline is primarily used as an intermediate for the synthesis of pharmaceuticals, dyes, and agrochemicals. It is a versatile starting material for the preparation of a wide range of organic compounds.
- In the pharmaceutical industry, orthofluoroaniline is used to produce drugs such as fluoroquinolone antibiotics and anti-inflammatory agents.
- In case of skin contact, the affected area should be washed thoroughly with
soap and water. In case of eye contact, the eyes
should be flushed with waterfor at least 15 minutes. If ingested, medical attention should be sought immediately. - In the dye industry, it is used as a precursor for the synthesis of fluorescent dyes and pigments.
- In the agrochemical industry, orthofluoroaniline is used as an intermediate in the production of herbicides and fungicides.
- Orthofluoroaniline is also used as a reagent in organic synthesis and as a standard in analytical chemistry.
Safety information for handling, packaging and storage:
- Orthofluoroaniline is considered to be harmful if ingested, inhaled, or absorbed through the skin. It may cause irritation to the eyes, skin, and respiratory system.
- Long-term exposure to orthofluoroaniline may cause damage to the liver, kidneys, and nervous system. It may also cause cancer in laboratory animals.
- Users should take appropriate precautions, including wearing protective clothing and gloves, and should avoid prolonged or repeated exposure to the substance.
- In case of skin contact, the affected area should be washed thoroughly with soap and water. In case of eye contact, the eyes should be flushed with water for at least 15 minutes. If ingested, medical attention should be sought immediately.
- Orthofluoroaniline should be stored in a cool, dry place away from sources of heat and ignition. It should be kept in a tightly closed container to prevent exposure to air and moisture.
- It should be handled with care to avoid exposure. Users should wear appropriate personal protective equipment, including gloves, eye protection, and a respirator if necessary.
- Spills or leaks should be cleaned up promptly using appropriate methods, and contaminated materials should be disposed of in accordance with local regulations.